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1960年,Nowell 和 Hungerford 在慢性粒细胞白血病(CML)病人中,发现了一个很小的异常性 G 组染色体,表现为中央着丝点,其 DNA 含量比其他 G 组染色体少40%,确定为长臂的缺失。他们以所在城市命名该染色体为 Philadelphia 染色体,简写为 Ph~1。约80～90%的 CML 病人骨髓分裂细胞中可见到Ph~1,称为 Ph~1(+)CML,其余10～15%的病人缺乏 Ph~1,称为 Ph~1(-)CML。多数 Ph~1(+)CML 病人骨髓分裂细胞中 Ph~1的出
In 1960, Nowell and Hungerford found a small group of abnormal G chromosomes in patients with chronic myeloid leukemia (CML), showing a centromeric centromere with a DNA content 40% less than that of other G chromosomes, identified as Lack of long arm. The city they named the chromosome was the Philadelphia chromosome, abbreviated Ph ~ 1. Ph ~ 1, called Ph ~ 1 (+) CML, is found in about 80 ~ 90% of myeloid cells in CML patients. Ph ~ 1 (-) CML is lacking in the remaining 10 ~ 15% of the patients. Most Ph ~ 1 (+) CML patients with bone marrow cells in the Ph ~ 1 out