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有报告偏头痛时5-羟色胺(5-HT)的主要分解产物5-羟吲哚乙酸在尿中的排泌增加,血小板5-HT 含量下降。Sumatriptan 是一种5-HT_1类激动剂,静脉和皮下给药可迅速消除偏头痛发作而仅有轻微的副作用。作者研究了 suma-triptan 口服给药治疗急性偏头痛的效果。病人和方法共61例进行试验,选择患者年龄18～60岁,每月必须有1～6次重度或中度的偏头痛发作,患偏头痛至少1年。作双盲、随机、配对(试验药/安慰剂)、交叉试验,
There is a report of increased excretion of urinary excretion of 5-hydroxyindoleacetic acid, a major 5-hydroxytryptamine (5-HT) -producing 5-HT, in platelet when migraine is reported. Sumatriptan is a 5-HT1 class of agonists, and intravenous and subcutaneous administration can quickly eliminate migraine attacks with only minor side effects. The authors studied the effect of oral administration of suma-triptan in the treatment of acute migraine. A total of 61 patients and methods were tested. Patients were selected from 18 to 60 years of age and had 1 to 6 severe or moderate migraine attacks per month and migraine headaches for at least 1 year. Double-blind, randomized, paired (test drug / placebo), crossover test,