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目的:探讨老年高血压患者血浆核因子(NF-κB)介导长五聚-3(PTX3)的表达情况及意义。方法:选取2015年10月到2016年6月收治年龄60-80岁初次诊断原发性高血压1级或2级并符合入选标准的患者,67例高血压患者按诊断级别进行分组(Grade I组、Grade II组),选取同期门诊非高血压病老年体检患者20例作为对照组(NHP组),各组患者分别检测外周血NF-κB和PTX3水平,外周血单核细胞加入NF-κB抑制剂吡咯烷二硫氨基甲酸(pyrrolidinedithiocarbamic acid,PDTC)后再次检测NF-κB和PTX3水平,组内及组间比较,进行统计学分析。结果:不同级别高血压组患者血浆NF-κB和PTX3水平均有所升高,较对照组差异有统计学意义(P<0.05)。不同级别高血压组之间PTX3水平有显著差异。加入NF-κB抑制剂后,两组高血压患者PTX3水平均降低,与对照组相比无统计学意义。同组比较,加抑制剂前后差别有统计学意义。结论:核因子-κB介导的PTX3表达升高可能参与了高血压的发生发展。
Objective: To investigate the expression and significance of nuclear factor-5 (PTX3) mediated by plasma nuclear factor (NF-κB) in elderly patients with hypertension. Methods: From October 2015 to June 2016, patients with grade-1 or grade-2 primary hypertension aged 60-80 years who met the inclusion criteria were enrolled. 67 hypertensive patients were grouped according to their diagnostic level (Grade I Grade II). 20 elderly patients with non-essential hypertension were enrolled as the control group (NHP group). The levels of NF-κB and PTX3 in the peripheral blood were measured in each group. The levels of NF-κB in peripheral blood mononuclear cells After pyrrolidineithiocarbamic acid (PDTC) inhibitor was used, the levels of NF-κB and PTX3 were detected again. The intra-and inter-group comparison was made for statistical analysis. Results: The plasma levels of NF-κB and PTX3 in patients with different levels of hypertension were significantly higher than those in the control group (P <0.05). There were significant differences in PTX3 levels between different levels of hypertension. After adding NF-κB inhibitor, the levels of PTX3 in both groups were decreased, which were not statistically significant compared with the control group. Compared with the same group, plus inhibitor before and after the difference was statistically significant. Conclusion: NF-κB mediated PTX3 expression may be involved in the development of hypertension.