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目的:探讨老年慢性心衰患者人高迁移率族蛋白B1(HMGB1)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、血管紧张素Ⅱ(AngⅡ)水平变化。方法:选择老年慢性心衰患者121例,正常对照组27例,分别通过心脏超声测量心脏射血分数(LVEF),酶联免疫法测定HMGB1、TNF-α、IL-6水平,放射免疫法测定AngⅡ水平,对检测结果进行统计学分析。结果:老年心衰患者LVEF明显低于对照组,而HMGB1、TNF-α、IL-6、AngⅡ水平明显高于对照组,两组比较有显著性差异(P<0.01)。结论:老年心衰患者HMGB1、TNF-α、IL-6、AngⅡ水平升高提示炎性细胞因子分泌过度增加,神经内分泌系统过度激活是导致CHF的病理生理机制之一。
Objective: To investigate the changes of high mobility group box 1 (HMGB1), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and angiotensin Ⅱ (AngⅡ) in elderly patients with chronic heart failure. Methods: 121 elderly patients with chronic heart failure and 27 normal controls were enrolled in this study. Cardiac ejection fraction (LVEF) was measured by echocardiography. The levels of HMGB1, TNF-α and IL-6 were determined by radioimmunoassay Ang Ⅱ level, the test results were statistically analyzed. Results: The LVEF of elderly patients with heart failure was significantly lower than that of the control group, while the levels of HMGB1, TNF-α, IL-6 and AngⅡ were significantly higher than those of the control group (P <0.01). CONCLUSION: Elevated HMGB1, TNF-α, IL-6 and AngⅡ levels in elderly patients with heart failure suggest that excessive secretion of inflammatory cytokines and excessive activation of the neuroendocrine system are one of the pathophysiological mechanisms leading to CHF.