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采用硫代巴比妥酸显色法,黄嘌呤氧化酶法和DTNB(5′-二硫代双二硝基苯甲酸法)测定50例水泥粉尘接触工人和50例健康对照工人血清MDA含量、SOD和POD活力,以探讨丙二醛(MDA)、超氧化物歧化酶(SOD)和过氧化物酶(POD)在水泥粉尘接触工人体内发生发展的意义。通过测定,结果显示,水泥粉尘接触工人血清MDA含量、SOD的活力较对照组比较,在统计学上无显著性差异(P>0.05),水泥接触工人血清POD的活力较对照组比较,有高度统计学意义(P<0.01)。说明水泥粉尘促进了机体脂质过氧反应水平,使机体抗氧化酶活力下降,显示了水泥粉尘对机体的早期损伤效应。
Serum MDA levels were measured in 50 cement dust exposure workers and 50 healthy workers by thiobarbituric acid chromogenic assay, xanthine oxidase assay and DTNB (5’-dithiobis dinitrobenzoic acid assay) SOD and POD in order to investigate the significance of malondialdehyde (MDA), superoxide dismutase (SOD) and peroxidase (POD) in cement dust exposure workers. The results showed that the serum MDA content and SOD activity of workers exposed to cement dust had no statistical difference (P> 0.05), the activity of serum POD in cement exposed workers was higher than that of the control group Statistical significance (P <0.01). Cement dust promote the level of lipid peroxidation, so that the body antioxidant enzyme activity decreased, showing the cement damage on the body early damage effect.