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目的探讨T2DM患者非酒精性脂肪肝病(NAFLD)与SUA水平的相关性。方法选取T2DM患者790例,检测临床实验指标,采用腹部彩色多普勒超声检查诊断NAFLD。根据是否合并NAFLD分为合并NAFLD(NAFLD)组219例和未合并NAFLD(N-NAFLD)组571例;根据SUA水平分为4组:Q1组202例(≤230μmol/L)、Q2组194例(231～287μmol/L)、Q3组194例(288～350μmol/L)和Q4组200例(≥351μmol/L)。结果 NAFLD组BMI、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(GGT)、TG、TC、LDL-C和SUA等均高于N-NAFLD组(P均<0.05);NAFLD组年龄和HDL-C低于N-NAFLD组(P均<0.05);其余指标两组间差异无统计学意义(P>0.05)。Q1～4组T2DM患者合并NAFLD的患病率分别为16.8%(34/202)、22.6%(44/194)、30.9%(60/194)和40.5%(81/200),4组间差异有统计学意义(χ2=31.71,P<0.001);校正相关因素后,Q4组NAFLD患病风险仍高于Q1组(OR3.19,95%CI 1.38～7.39)。结论 T2DM患者NAFLD与SUA有相关性,高SUA水平可能是T2DM患者NAFLD发生的独立相关因素。
Objective To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and SUA in T2DM patients. Methods Totally 790 T2DM patients were selected to detect clinical laboratory parameters. Abdominal color Doppler ultrasonography was used to diagnose NAFLD. According to whether the NAFLD was merged, there were 219 cases with NAFLD (NAFLD) and 571 cases with NAFLD (NAFLD). According to SUA level, there were 4 groups: 202 cases in Q1 group (≤230μmol / L) and 194 cases in Q2 group (231 ~ 287μmol / L), Q3 group, 194 cases (288 ~ 350μmol / L) and Q4 group, 200 cases (≥351μmol / L). Results The levels of BMI, ALT, AST, GGT, TG, TC, LDL-C and SUA in NAFLD group were significantly higher than those in NAFLD group N-NAFLD group (all P <0.05). The age and HDL-C of NAFLD group were lower than those of N-NAFLD group (all P <0.05). There was no significant difference between the other two groups (P> 0.05). The prevalence rates of NAFLD in T1 ~ 4 T2DM patients were 16.8% (34/202), 22.6% (44/194), 30.9% (60/194) and 40.5% (81/200), respectively (Χ2 = 31.71, P <0.001). After adjusting for related factors, the risk of NAFLD in Q4 group was still higher than that in Q1 group (OR3.19,95% CI 1.38 ~ 7.39). Conclusions There is a correlation between NAFLD and SUA in T2DM patients. High levels of SUA may be an independent factor of NAFLD in T2DM patients.