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目的探讨Survivin与p53在皮肤癌中的表达及其临床意义。方法40例经常规石蜡包埋皮肤鳞状细胞癌和基底细胞癌标本,镜检确定组织学类型,应用免疫组织化学S-P法检测Survivin和p53蛋白表达。结果Survivin低分化有淋巴结转移者,其阳性表达率较高(P均<0.05);p53阳性表达者的淋巴结转移率大于阴性表达者(P均<0.05)。皮肤癌Survivin蛋白阳性病例中p53蛋白阳性表达率为28.6%(8/28),而Survivin阴性病例中p53阳性表达率为66.7%(8/12),两者之间呈负相关(r=-0.3,P<0.05)。结论Survivin蛋白的表达与皮肤癌预后有相关的联系。p53基因突变在皮肤癌的发展和淋巴转移过程中起着重要的作用。Survivin与p53呈负相关。
Objective To investigate the expression of Survivin and p53 in skin cancer and its clinical significance. Methods Forty cases of paraffin-embedded skin squamous cell carcinoma and basal cell carcinoma were examined by histological examination. Survivin and p53 protein expressions were detected by immunohistochemical S-P method. Results The positive rates of Survivin in poorly differentiated lymph node metastasis were higher (all P <0.05). The rates of lymph node metastasis were higher in patients with positive p53 protein than in negative ones (all P <0.05). The positive rate of p53 protein was 28.6% (8/28) in Survivin protein positive cases, and 66.7% (8/12) in Survivin negative cases. There was a negative correlation between them (r = - 0.3, P <0.05). Conclusion The expression of Survivin is correlated with the prognosis of skin cancer. The mutation of p53 gene plays an important role in the development of skin cancer and lymphatic metastasis. Survivin is negatively correlated with p53.