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采用大鼠全脑缺血模型、观察脑缺血再灌流过程中海马神经元的病理变化，并用尼莫地平（钙拮抗剂）及ＭＫ－８０１（ＮＭＤＡ受体拮抗剂）治疗，观察其对迟发性神经元坏死的疗效，旨在探讨钙及兴奋性氨基酸在海马神经元缺血损害中的作用，为缺血性脑损伤的治疗探索新的途径。
The rat model of global cerebral ischemia was used to observe the pathological changes of hippocampal neurons during cerebral ischemia-reperfusion. Nimodipine (calcium antagonist) and MK-801 (NMDA receptor antagonist) The purpose of this study is to explore the role of calcium and excitatory amino acids in the ischemic damage of hippocampal neurons and explore new ways for the treatment of ischemic brain injury.