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目的探索银杏内酯注射液在静脉给药后产生的Ⅰ型过敏反应,为临床安全用药提供参考。方法采用豚鼠做全身主动过敏试验;采用BALB/c小鼠制备抗血清,以SD大鼠做被动皮肤过敏试验。结果全身主动过敏试验致敏期间和激发后给药组和阴性组豚鼠无异常症状,阳性组豚鼠出现明显过敏症状;被动皮肤过敏试验给药组和阴性组大鼠背部未出现蓝斑,阳性组蓝斑直径均值>5 mm。结论银杏内酯注射液在此试验条件下,全身主动过敏和被动皮肤过敏试验结果为阴性。
Objective To explore the type Ⅰ allergic reaction induced by ginkgolide injection after intravenous administration, so as to provide a reference for clinical safe medication. Methods Guinea pigs were used to make whole body active allergy test. BALB / c mice were used to prepare antiserum and SD rats were used as passive skin allergy test. Results There were no abnormal symptoms in the whole body active allergy test during the sensitization and in the guinea pigs in the challenge group and in the negative group. The positive group showed obvious allergy symptoms. The passive skin allergy test in the control group and the negative group showed no blue spot in the back, The mean spot diameter is> 5 mm. Conclusion Ginkgolide injection in this test conditions, the whole body active and passive skin allergy test results were negative.