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单克隆抗体使对许多白细胞表面分子可以进行分类。绘制免疫系统细胞表面图谱可以鉴别细胞分化,了解其功能、生长和恶性病变。白细胞分型在临床医学中也应用日广。仅在12年前Kohler和Milstein发表了关于单克隆抗体产生的经典论述。将产生抗体的B细胞与恶性浆细胞瘤的细胞相对物融合,得出永生的杂交细胞培养株,可产生无限量特异性抗体。1970年Kung等揭示抗T细胞表面的单克隆抗体OK(Ortho,Kung)系列。这些单克隆抗体可剖析T细胞受体复合物的成分。
Monoclonal antibodies allow the classification of many leukocyte surface molecules. Mapping the immune system’s cell surface maps differentiates cell differentiation, understanding its function, growth, and malignancy. Leukocyte typing is also widely used in clinical medicine. Just over 12 years ago, Kohler and Milstein published a classic treatise on the production of monoclonal antibodies. The antibody-producing B cells are fused with the cell counterpart of the malignant plasmacytoma resulting in an immortalized hybrid cell culture that produces an unlimited number of specific antibodies. 1970 Kung et al. Revealed a series of monoclonal antibodies OK (Ortho, Kung) on the surface of anti-T cells. These monoclonal antibodies can profile the components of the T cell receptor complex.