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本文作者研究的目的是确定在不同恶性肿瘤中,大剂量环磷酰胺(Cy)动员后,对能收集到合适数量的周血造血祖细胞的影响因素。自1988年2月至1991年12月,60例病人进行了这个研究,其中淋巴瘤27例,多发性骨髓瘤(MM)6例,乳腺癌17例,其他晚期恶性实体瘤10例。动员前既往治疗者,淋巴瘤121例,MM5例,实体瘤10例。动员剂为单剂量Cy(4或7g/m~2)2小时输注,当周血中中性粒细胞绝对数(ANC)超过0.8×10~9/L 时采集周血干细胞。每例病人每疗程进行4～
The aim of this study was to determine the factors that influence the collection of the appropriate number of peripheral blood progenitor cells after mobilization of large doses of cyclophosphamide (Cy) in different malignancies. From February 1988 to December 1991, 60 patients underwent this study, of which 27 were lymphoma, 6 with multiple myeloma (MM), 17 with breast cancer, and 10 with other advanced malignant solid tumors. Past mobilization before mobilization, lymphoma in 121 cases, MM5 cases, solid tumors in 10 cases. Mobilization agents were infused with single dose of Cy (4 or 7g / m ~ 2) for 2 hours. Peripheral blood stem cells were collected when the absolute neutrophil count (ANC) of peripheral blood exceeded 0.8 × 10 ~ 9 / L. Each patient for each course of 4 ~