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最近发现,阵发性睡眠性血红蛋白尿(PNH)患者血细胞膜缺乏磷脂酰肌醇聚糖(PIG)参与构成的表面分子。作者用免疫荧光法检测PNH 患者外周血细胞PIG-表面分子,以明确其对PNH 诊断的意义。12例PNH 受检者均为酸溶血试验阳性。经抗PIG-表面分子的单克隆抗体CD59(红细胞)、CD55(多形核中性粒细胞)和CD48(淋巴细胞和单核细胞)等检测表明,全部患者的红细胞、中性粒细胞和单核细胞均有PIG-表面分子缺乏细胞;11例患者的
It has recently been found that the plasma membrane of patients with paroxysmal nocturnal hemoglobinuria (PNH) lacks phosphatidylinositol (PIG) involved in the formation of surface molecules. The authors used immunofluorescence method to detect peripheral blood cells in patients with PNH PIG-surface molecules, in order to clarify its significance in the diagnosis of PNH. 12 cases of PNH subjects were acid-base hemolysis test. Detection of monoclonal antibodies against PIG-surface molecules such as CD59 (erythrocytes), CD55 (polymorphonuclear neutrophils) and CD48 (lymphocytes and monocytes) showed that all patients had erythrocytes, neutrophils and mono All of the nucleated cells had PIG-deficient cells in the surface molecule; 11 patients