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由于酞咪呱啶酮(反应停)可致严重胎儿畸形曾被摒弃,但自1956年Sheskin报告用以治疗麻风反应取得成效后,又引起了人们对这药的兴趣.目前对其作用机理进行的许多研究,有部分结果是很矛盾的.反应停造成畸胎的机理也还不清楚.反应停的药理和作用机理的研究反应停在口服后分布于全身器官,一次给药后大约4小时消化道组织和肾脏中达到最高浓度,随着时间的推移,在血细胞、肾脏、肝脏、脑和皮肤中的含量也逐渐增多.它
Because of phthalopridone (reaction stop) can cause severe fetal malformations have been abandoned, but since 1956 Sheskin report to be effective in treating leprosy, but also caused the people’s interest in this drug now its mechanism of action Of the many studies, some of the results are very contradictory.Factory mechanism of teratogenic reaction is not yet clear.Study on pharmacokinetics and mechanism of action of the reaction stopped after oral administration in the body organs, after a dose of about 4 hours The highest concentration is reached in the digestive tract tissues and kidneys, and over time, it increases in the blood cells, kidneys, liver, brain and skin.