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Tracy和Webster曾报道了在哺乳类动物肠内的微生物能将硝唑咪转化为1-硫氨荒酰-2-咪唑酮(TCI),而曼氏血吸虫是一种兼性厌氧生物。因此,作者推测了这种多细胞寄生虫也与某些细菌一样。产生TCI。作者通过高压液相方法在曼氏血吸虫中分离到了TCI。并经过高时电冲击式质谱镜鉴定了它是一种硝唑咪在血吸虫中的代谢产物。在含10μg/ml(5.2Ci/ml)的硝唑咪
Tracy and Webster have reported that microorganisms in mammalian intestines convert nitazoxanide to 1-thiaminain-2-imidazolidinone (TCI), which is a facultative anaerobic organism. Therefore, the authors speculate that this multicellular parasite is also similar to some bacteria. Generate TCI. The authors isolated TCI from Schistosoma mansoni by high-pressure liquid-phase method. And after high-power electric impact spectroscopy identified it as a nitrofolate in Schistosoma metabolites. In the containing 10μg / ml (5.2Ci / ml) of nitazoxanide