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本实验用水杨酸钠灌胃诱导大鼠胃粘膜损伤的同时,再用“饥饱失常”、“劳倦过度”的方法制造出脾气虚证,分别用香砂六君子汤和维酶素防治。结果表明:前者抗大鼠胃粘膜损伤并脾气虚证的作用,优于维酶素(P<0.01)并对各组胃窦G细胞进行观察,发现单纯造模组G细胞数目减少,与中药组比较,差异有显著意义(P<0.05);与维酶素组比较,差异无显著性意义(P>0.05),提示香砂六君子汤对胃肠内分泌系统有一定的调节作用。
In this experiment, gastric ulceration induced by sodium salicylate in rats was induced. At the same time, the “deficiency and hunger” and “overwork and fatigue” methods were used to create spleen-deficiency syndromes, which were controlled by Xiangsha Liujunzi Decoction and vitamins. The results showed that the former had better effect on rat gastric mucosal damage and deficiency of spleen-qi than that of viroid (P<0.01). G-cells in gastric antrum of each group were observed and the number of G cells in the simple model group was decreased. There was a significant difference between the two groups (P<0.05). There was no significant difference between the group and the retinoid group (P>0.05), suggesting that Xiangsha Liujunzi Decoction has a certain regulatory effect on the gastrointestinal endocrine system.