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文献中有关利用药物预防抗生素对听分析器有害作用的材料极少。由于耳蜗血供方面的解剖和生理特点,氧气到达内耳的过程少有代偿的可能性。氨基糖苷类抗生素能减少耳蜗淋巴液中的氧含量,从而导致毛细胞琥珀酸脱氢酶活性的显著降低(Ayani et al,1976)。烟酰胺可在各组织和器官中大量积聚并作为脱氢酶辅酶的烟酰胺腺嘌呤二核苷酸而参与一系列氧化还原反应。作者们用40只猫通过电生理学方法研究了局部应用单霉素(monomycin)时烟酰胺的预防耳毒性的效果。动物按照局部应用20%抗生素溶液的同时是否还应用烟酰胺,以及所用烟酰胺的剂量和应用
There are very few documents in the literature regarding the use of drugs to prevent antibiotics from detrimental to the analyzer. Due to the anatomical and physiological characteristics of the cochlear blood supply, there is little likelihood of oxygen reaching the inner ear compensatory. Aminoglycosides reduce oxygen levels in cochlear lymphatics, leading to a significant reduction in hair cell succinate dehydrogenase activity (Ayani et al., 1976). Nicotinamide can accumulate in various tissues and organs and participate in a series of redox reactions as nicotinamide adenine dinucleotide, a dehydrogenase coenzyme. The authors studied the preventive effect of niacinamide against ototoxicity by topical application of monomycin using electrophysiological methods in 40 cats. Animals are also given nicotinamide at the same time as the 20% antibiotic solution applied topically, and the dose and use of nicotinamide used