论文部分内容阅读
目的分析糖皮质激素治疗对哮喘患者胰岛素及其受体的表达的影响。方法选取南阳市第一人民医院收治的支气管哮喘患者30例,设为观察组,给予患者连续1个月糖皮质激素治疗,测定治疗前后患者空腹血糖含量和血清内胰岛素含量,并采用酶联免疫吸附法对患者血清内可溶性胰岛素受体含量进行测定,并与同期收治的健康体检者(对照组)进行对比。结果治疗前哮喘患者血清胰岛素含量和胰岛素受体含量均高于健康人,经1个月的糖皮质激素治疗,血清胰岛素含量和胰岛素受体含量明显降低,与治疗前相比差异有统计意义(P<0.05)。结论糖皮质激素可有效改善哮喘患者肺功能,调节其胰岛素及胰岛素受体表达。
Objective To analyze the effect of glucocorticoid treatment on the expression of insulin and its receptor in asthmatic patients. Methods A total of 30 patients with bronchial asthma admitted to First People’s Hospital of Nanyang City were enrolled in this study. The patients were treated with glucocorticoid for 1 month continuously. The fasting blood glucose and serum insulin levels were measured before and after treatment. Enzyme linked immunosorbent assay The content of soluble insulin receptor in serum of patients was determined by adsorption method and compared with the healthy subjects (control group) who were treated in the same period. Results Serum insulin and insulin receptor were higher in patients with asthma before treatment than those in healthy people. After 1 month of glucocorticoid treatment, the levels of serum insulin and insulin receptor were significantly decreased, which were significantly different from those before treatment P <0.05). Conclusion Glucocorticoids can effectively improve lung function and regulate insulin and insulin receptor expression in asthmatic patients.