论文部分内容阅读
目前临床用于治疗真菌感染的药物多为抗菌谱广、抗菌(?)性强以及耐受性良好的唑类抗真菌药。为麦角甾醇生物合成的强抑制剂。麦角甾醇则为形成完整真菌细胞膜的主要成分。该类化合物的作用部位是抑制真菌细胞内细胞色素P-450所发生的C_(14)去甲基
Currently clinically used for the treatment of fungal infections are mostly antibacterial spectrum, antimicrobial (?) Strong and well tolerated azole antifungal agents. Strong inhibitor of ergosterol biosynthesis. Ergosterol is the main component that forms the complete fungal cell membrane. The site of action of these compounds is inhibiting the C_ (14) demethylation of cytochrome P-450 in fungal cells