肝炎性假瘤合并克罗恩病病例报道

• 作 者: Papachristou G.I.sh W. Plevy S.E. 王志宇
• 机 构: Div. Gastroenterol., Hepatol.,/Nutr., Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, United
• 出 处: 世界核心医学期刊文摘(胃肠病学分册)
• 发表日期: 2005年03期
• 关键词: 克罗恩病 肝炎性假瘤 炎症性肠病 肝肿块 逆行胆管造影 炎性假瘤 病例 胆管癌 胆管狭窄 炎性细胞浸润

Inflammatory pseudotumor (IPT) of the liver is a rare, benign lesion that is characterized by proliferating fibrous tissue infiltrated by inflammatory cells. The exact etiology of IPT remains unclear. Although the association of IPT with systemic inflammatory disorders has been established, a specific link with Crohns disease is rare. We report two cases of IPT associated with Crohns disease. Both patients were elderly males who presented with abdominal pain and jaundice. At the time of presentation, both had active Crohns disease that was undiagnosed. Computed tomography demonstrated a liver mass, and endoscopic retrograde cholangiography revealed biliary strictures in both patients. Given their symptomatic jaundice and concern for cholangiocarcinoma, they underwent abdominal surgical exploration and pathology results revealed IPT. They were subsequently diagnosed with Crohns disease. Following treatment of Crohns disease, there was significant improvement in their overall clinical status. An underlying diagnosis of inflammatory bowel disease should be considered in patients with IPT.

Inflammatory pseudotumor (IPT) of the liver is a rare, benign lesion that is characterized by proliferating fibrous tissue infiltrated by inflammatory cells. The exact etiology of IPT remains unclear. Although the association of IPT with systemic inflammatory disorders has been established, a specific link with Crohn’s disease is rare. We report two cases of IPT associated with Crohn’s disease. Both patients were elderly males who presented with abdominal pain and jaundice. At the time of presentation, both had active Crohn’s disease that was undiagnosed Computed tomography demonstrated a liver mass, and endoscopic retrograde cholangiography revealed biliary strictures in both patients. Given their symptomatic jaundice and concern for cholangiocarcinoma, they underwent abdominal surgery exploration and pathology results revealed IPT. They were followed diagnosed with Crohn’s disease. Following treatment of Crohn’s disease, there was significant improvement in their over all clinical status. An underlying diagnosis of inflammatory bowel disease should be considered in patients with IPT.