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目的:对正常孕妇及子宫颈癌患者的血清碱性磷酸酶(ALP)活性进行检测以了解碱性磷酸酶活性在该人群中的的变化及临床意义。方法:测定2006～2007年我院483名正常孕妇和198名子宫颈癌患者ALP值。结果:正常孕妇ALP活性在孕期3、4月中大致正常,从第五月孕月起活性水平持续上升,从第7、8、9孕月活性中大幅上升,与3、4、5、6月比较P<0.05有显著性意义。子宫颈癌患者的早、中期都有ALP活性的升高,但活性水平都不高,在晚期其活性水平大幅增高,与早、中期比较P<0.05有显著意义。结论:ALP作为常用的肝胆系统生化指标,对妊娠妇女和子宫颈癌患者的应用价值受到很大限制,其在上述人群中的作用有待进一步研究。
Objective: To detect the serum alkaline phosphatase (ALP) activity of normal pregnant women and patients with cervical cancer in order to understand the changes of alkaline phosphatase activity in this population and its clinical significance. Methods: The ALP of 483 normal pregnant women and 198 cervical cancer patients from 2006 to 2007 in our hospital were determined. Results: The activity of ALP in normal pregnant women was generally normal during the third and fourth trimester of pregnancy. The activity level increased continuously from the fifth trimester of pregnancy and rose significantly from the seventh, eighth and ninth trimesters of activity, Month P <0.05 was significant. Cervical cancer patients had elevated ALP activity in early and mid-term, but the activity level is not high, the level of activity increased significantly in late stage, compared with early and mid-term P <0.05 significant. CONCLUSIONS: ALP, as a common biochemical indicator of hepatobiliary system, has great limitations on the value of application in pregnant women and cervical cancer patients. The role of ALP in these populations remains to be further studied.