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目的探讨双水平气道正压(BIPAP)呼吸机配合健脾益肺方治疗肌萎缩侧索硬化(ALS)并发呼吸衰竭患者的临床疗效。方法 9例ALS并发呼吸衰竭患者治疗期间给予营养支持、对症处理,在使用BIPAP呼吸机治疗的基础上加用健脾益肺方颗粒,每日1剂,分两次冲服,连续治疗1个月。治疗前后采用电极法测定pH值、二氧化碳分压(PCO2)、氧分压(PO2)血气分析,记录BIPAP呼吸机使用时间及ALS自我评估问卷(ALSAQ-40)评分。结果治疗后患者PCO2、PO2水平与治疗前比较明显好转,差异均有统计学意义(P<0.05);治疗后患者使用BIPAP呼吸机时间明显缩短(P<0.05);治疗后ALSAQ-40量表情绪反应评分有所改善,与治疗前比较差异有统计学意义(P<0.05),其他各项评分比较差异均无统计学意义(P>0.05)。结论 BIPAP呼吸机配合健脾益肺方可有效缓解ALS并发呼吸衰竭患者呼吸肌疲劳,改善其呼吸功能,并缩短BIPAP呼吸机使用时间,改善其症状。
Objective To investigate the clinical efficacy of BIPAP combined with Jianpi Yifei Fang in the treatment of amyotrophic lateral sclerosis (ALS) complicated with respiratory failure. Methods Nine patients with ALS complicated with respiratory failure were given nutrition support and symptomatic treatment. The patients were treated with BIPAP ventilator for one month, twice a day, once a day . Before and after treatment, pH, PCO2, PO2 blood gas were measured by electrode method. The BIPAP ventilator time and ALSQ-40 score were recorded. Results After treatment, the levels of PCO2 and PO2 were significantly improved compared with those before treatment (P <0.05), and the duration of BIPAP ventilator time was significantly shorter after treatment (P <0.05). After treatment, the ALSAQ-40 scale The score of emotional reaction was improved, which was significantly different from that before treatment (P <0.05). There was no significant difference between the other scores (P> 0.05). Conclusion BIPAP ventilator combined with Jianpi Yifei can effectively relieve respiratory muscle fatigue and improve respiratory function in patients with ALS complicated with respiratory failure, and shorten the time of BIPAP ventilator and improve its symptoms.