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目的：观察高通量血液透析治疗终末期肾衰竭的效果。方法选取我院住院治疗的65例终末期肾衰竭患者，随机将患者分为高通量透析组26例、常规透析组20例和血液灌流组19例。分别于治疗前、治疗6个月后检测患者透析前血清肌酐(Scr)、尿素氮(BUN)、电解质6项、β2微球蛋白(β2-MG)、血清白蛋白(ALB)、血红蛋白(Hb)、总蛋白(TP)、血清磷(PO4-3)和全段甲状旁腺激素(iPTH)，观察患者并发症发生率。结果高通量组终末期肾衰竭患者治疗后β2-MG、iPTH、Hb、TP、PO4-3和ALB指标均优于其他两组，差异有统计学意义(P<0.05)。高通量血液透析组患者心力衰竭、心率失常和血压异常并发症均低于常规透析组和血液灌流组，其总并发症例数的差异有统计学意义（P<0.05）。结论采用高通量血液透析治疗终末期肾衰竭患者，对患者的血液内有害物质的清除能力、营养状况的改善以及并发症发生率的控制较常规透析有明显的提升。“,”Objective To analyze the effect of high-flux hemodialysis in the treatment of patients with end-stage renal failure. Methods A total of 65 patients with high-flux hemodialysis which from inpatient were divided into high-flux hemodialysis group (26 cases), conventional hemodialysis group (20 cases) and hemoperfusion group (19 cases). After 6-month treatment, biochemical indicators, such as serum creatinine(Scr), blood urea nitrogen(BUN), β2-microglobulin(β2-MG), albumin(ALB), hemoglobin(Hb), total protein(TP), iPTH , serum phosphorus(PO4-3) and complication were measured.Results The biochemical indicators of high-flux hemodialysis group, including β2-MG, ALB, Hb, TP , PO4-3 and iPTH were improved better after treatment than those in conventional hemodialysis group and hemoperfusion group. There were significant differences in high-flux hemodialysis group and other two group (P<0.05). Besides, compared with conventional hemodialysis group and hemoperfusion group, high-flux hemodialysis group had lower complication rates, including heart failure, arrhythmias and abnormal blood pressure. There were significant differences in total complication cases (P<0.05).Conclusion For patients with end-stage renal failure, it could improve the blood of harmful substances removal efficiency, and complication rate by high-flux hemodialysis treatment.