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目的：报告 20例恶性淋巴瘤在自体造血干细胞移植支持下接受超大剂量化疗的初步治疗经验 ,评价所用外周血造血干细胞 (peripheral blood progenitors,PBPC )动员方案的动员效果，预处理方案的远期疗效和耐受性，以及回输后造血重建情况。方法： 20例复发、晚期恶性淋巴瘤中， 1例复发霍奇金病 (Hodgkin s disease,HD),19例非霍奇金淋巴瘤 (non- Hodgkin s lymphoma,NHL）。经常规化疗获缓解后， 3例采用自体骨髓移植 (autologous bone marrow transplantation,ABMT)， 17例采用自体外周血干细胞移植 (autologous peripheral blood stem cell transplantation,APBSCT)；动员方案为环磷酰胺 (CTX)3 500 mg/m2＋ G- CSF 3.5～ 5μ g/kg＋地塞米松 10 mg，预处理方案为 BEAC(CTX 3 600～ 4 000 mg/m2,Vp- 16 1 200 mg/m2,BCNU 300 mg/m2和 Ara- C 1 500～ 2 000 mg/m2),化疗结束后 24～ 48 h回输自体造血干细胞。结果： ABMT病人回输单核细胞 (MNC)1.3(1.0～ 1.7)× 108/kg， APBSCT病人回输 MNC 1.8(1.0～ 4.4)× 108、 CFU- GM 5.1 (1.9～ 9.6 )× 105/kg和 CD34＋细胞 2.9(1.9～ 8.7)× 106/kg。回输造血干细胞后均获快速造血功能重建，中性粒细胞 (ANC)≥ 0.5× 109/L时间为 9(6～ 17)天，血小板≥
OBJECTIVE: To report preliminary experience in the treatment of 20 cases of malignant lymphoma receiving super-dose chemotherapy with the support of autologous hematopoietic stem cell transplantation, evaluate the mobilization effect of peripheral blood progenitors (PBPC) mobilization program, and the long-term efficacy of the pretreatment regimen. And tolerability, and hematopoietic reconstitution after transfusion. METHODS: Of the 20 relapsed and advanced malignant lymphomas, 1 was recurrent Hodgkin’s disease (HD) and 19 were non-Hodgkin’s lymphoma (NHL). After remission by conventional chemotherapy, autologous bone marrow transplantation (ABMT) was used in 3 cases, autologous peripheral blood stem cell transplantation (APBSCT) in 17 cases, and cyclophosphamide (CTX) was the mobilization protocol. 3 500 mg/m2 G-CSF 3.5 to 5 μg/kg+dexamethasone 10 mg, pretreatment protocol for BEAC (CTX 3 600 to 4 000 mg/m2, Vp- 16 1 200 mg/m2, BCNU 300 mg/m2 And Ara-C 1 500-2 000 mg/m2), autologous hematopoietic stem cells were returned 24 to 48 h after chemotherapy. Results: ABMT patients returned mononuclear cells (MNC) 1.3 (1.0 ~ 1.7) × 108/kg, APBSCT patients returned MNC 1.8 (1.0 ~ 4.4) × 108, CFU-GM 5.1 (1.9 ~ 9.6) × 105/kg And CD34+ cells were 2.9 (1.9 to 8.7) x 106/kg. All hematopoietic stem cells were reconstructed after hematopoietic stem cell reconstitution. The neutrophil (ANC) ≥ 0.5×109/L was 9 (6 to 17) days. Platelet ≥