氨基酰合成酶类和肺腺癌生存概率的关系*

• 作 者: 李岩 熊延路 思越 潘明宏 石明延 卢强 李小飞 韩勇
• 机 构: 空军军医大学唐都医院胸腔外科,陕西 西安,710038;空军军医大学基础医学院学员队,陕西 西安,710032
• 出 处: 医学临床研究
• 发表日期: 2019年10期
• 关键词: Lung Neoplasms／EN Amino Acyl tRNA Synthetases

[目的]探讨氨基酰tRNA合成酶类和肺腺癌生存概率的联系.[方法]首先从 TCGA平台中获取肺腺癌的基因表达数据和临床记录;然后应用 GSEA分析方法获取氨基酰tRNA合成酶家族在肺腺癌中的整体表达特点;最后分析该代谢酶家族和肺腺癌总生存期以及无进展生存期的关系.[结果]氨基酰tRNA合成酶家族在肺腺癌中显著高表达;生存分析发现 7 种酶和肺腺癌总生存期有关,4 种酶和无进展生存期有关,这些酶的高表达预示患者预后较差.[结论]氨基酰tRNA合成酶家族在肺腺癌中整体高表达,且和生存概率密切相关,这为理解肺腺癌的代谢特点以及防治方法提供一定借鉴意义.“,”[Objective]To explore the association between aminoacyl tRNA synthetases and survival probability of lung adenocarcinoma via integrated analysis.[Methods]We first obtained the gene expression data and clinical records of lung adenocarcinoma from the TCGA platform.Then we used GSEA analysis to explore the overall expression status of the aminoacyl tRNA synthetase family in lung adenocarcinoma.Finally,we analyzed the relationship of the metabolic enzymes with total survival and progressionfree survival of lung adenocarcinoma.[Results]We found that the aminoacyl tRNA synthetase family was highly expressed in lung adenocarcinoma.Survival analysis revealed that seven out of these enzymes were associated with overall survival of lung adenocarcinoma,and four enzymes were associated with progressionfree survival.Patients with high expression of these enzymes showed worse prognosis.[Conclusion]AminoacyltRNA synthetases are highly expressed in lung adenocarcinoma and are closely related to survival probability.This provides a reference for understanding the metabolic characteristics and prevention methods of lung adenocarcinoma.