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The title compound was synthesized and its crystal structure was determined by single-crystal X-ray diffraction. The crystal is of orthorhombic system (C22H22N2O4, Mr = 378.42), space group P2121 with a = 6.8786(12), b = 14.259(2), c = 19.712(3) , V = 1933.5(6)3, Z = 4, Dc = 1.300 g/cm3, F(000) = 800, μ = 0.090 mm-1, the final R = 0.0324 and wR = 0.0775 for 2410 observed reflections (I > 2σ(I)). The structure, especially the absolute configuration, of the title compound ambrisentan, an important endothelin receptor antagonist, was confirmed by single-crystal X-ray diffraction. The three aromatic rings in the lattice are basically orthogonal to one another. There is an intermolecular hydrogen bond in the crystal, which helps to further stabilize the crystal. One of the two non-classical intramolecular hydrogen bonds can help to stabilize the molecular conformation in the lattice.
The title compound was synthesized and its crystal structure was determined by single-crystal X-ray diffraction. The crystal is of orthorhombic system (C22H22N2O4, Mr = 378.42), space group P2121 with a = 6.8786 (12), b = 14.259 ), c = 19.712 (3) , V = 1933.5 (6) 3, Z = 4, Dc = 1.300 g / cm3, F (000) = 800 and μ = 0.090 mm- The structure, especially the absolute configuration, of the title compound ambrisentan, an important endothelin receptor antagonist, was confirmed by single-crystal X-ray diffraction. The three aromatic There are an intermolecular hydrogen bond in the crystal, which helps to further stabilize the crystal. One of the two non-classical intramolecular hydrogen bonds can help to stabilize the molecular conformation in the lattice.