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目的观察人血免疫球蛋白治疗小儿癫痫的临床疗效及对免疫功能的影响。方法选取2010年1月至2012年1月就诊的癫痫患儿35例(癫痫组),采用静脉滴注人血免疫球蛋白400 mg·kg-1·d-1治疗,连续5 d为1个疗程,每个月治疗1个疗程,共治疗3个月,观察其疗效;以健康体检儿童35例为对照组,采用免疫比浊法检测对照组儿童及癫痫组患儿治疗前后血清免疫球蛋白lgA、lgG、lgM水平;流式细胞仪检测淋巴细胞亚群CD3+、CD4+的百分比。结果癫痫组患儿治疗前的lgA、lgG、lgM、CD3+、CD4+较对照组明显降低(P<0.05或P<0.01);治疗3个月后癫痫患儿的lgA、lgG、lgM、CD3+、CD4+较治疗前均明显升高(P<0.05或P<0.01)。癫痫患儿经3个疗程免疫球蛋白治疗,完全控制8例,显效9例,有效8例,总有效率71.4%。结论人血免疫球蛋白能提高癫痫患儿的免疫功能,有较好的疗效。
Objective To observe the clinical efficacy of human immunoglobulin in the treatment of children with epilepsy and its effect on immune function. Methods Thirty-five children with epilepsy (epilepsy group) treated from January 2010 to January 2012 were enrolled in this study. The patients were treated with intravenous infusion of 400 mg · kg -1 · d -1 human immunoglobulin for one week Course of treatment, a course of treatment each month, a total of 3 months treatment, to observe its efficacy; healthy children 35 cases of control group, the use of immune turbidimetry in children with control group and epilepsy group before and after treatment of serum immunoglobulin lgA, lgG, lgM levels; flow cytometry lymphocyte subsets CD3 +, CD4%. Results The levels of lgA, lgG, lgM, CD3 + and CD4 + of children with epilepsy before treatment were significantly lower than those of the control group (P <0.05 or P <0.01) Than before treatment were significantly higher (P <0.05 or P <0.01). Children with epilepsy after 3 courses of immunoglobulin treatment, complete control in 8 cases, markedly effective in 9 cases, effective in 8 cases, the total effective rate was 71.4%. Conclusion Human immunoglobulin can improve immune function in children with epilepsy and has good curative effect.