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目的：探讨内毒素休克家兔血浆及肝、脾、肾、心、肺脏等重要器官中内源性一氧化碳（ＣＯ）的含量变化以及血红蛋白氧合酶抑制剂——锌原卟啉对其的影响。方法：将实验家兔分为３组：对照组、内毒素休克组和锌原卟啉治疗组，用Ｃｈａｌｍｅｒｓ血红蛋白结合及联二亚硫酸盐法测定ＣＯ含量。结果：内毒素休克组血浆ＣＯ含量于内毒素注射后迅速增高，肝、脾、心、肺脏ＣＯ含量亦明显增高；使用锌原卟啉能显著抑制血浆以及肝、脾、心、肺脏ＣＯ水平的增高，并可显著减轻内毒素所致的血压下降和代谢性酸中毒状况。结论：ＣＯ是一种新的内源性介质，参与了内毒素休克的一系列病理生理过程
OBJECTIVE: To investigate the changes of endogenous carbon monoxide (CO) in plasma, liver, spleen, kidney, heart, lung and other vital organs in rabbits with endotoxin shock and the effect of hemoglobin oxygenase inhibitor zinc protoporphyrin . Methods: The experimental rabbits were divided into 3 groups: control group, endotoxin shock group and zinc protoporphyrin treatment group. CO content was determined by Chalmers hemoglobin binding and dithionite method. Results: In the endotoxic shock group, the content of CO in plasma increased rapidly after endotoxin injection, and the content of CO in liver, spleen, heart and lung were also significantly increased. Using zinc protoporphyrin significantly inhibited the plasma CO and the CO level in liver, spleen, heart and lung Increase, and can significantly reduce endotoxin-induced blood pressure and metabolic acidosis. Conclusion: CO is a new endogenous mediator involved in a series of pathophysiological processes of endotoxic shock