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肉毒杆菌毒素与胆碱能神经的突触前膜结合,抑制乙酰胆碱的释放,产生局部的胆碱能神经支配丧失。到目前为止,几乎没有肉毒杆菌毒素是否能抑制副交感胆碱能神经突触前末梢乙酰胆碱释放的研究。本研究中,作者检验了纯化的肉毒杆菌毒素A和D非致死量下在颌下腺中的抗胆碱作用。靶神经纤维为行走于舌神经,支配颌下腺腺泡和导管的节后副交感神经元。 材料和方法 雄性杂种狗(18～20kg)20只。全麻后颌下腺注射肉毒杆菌毒素。在颈部分离舌神经,用双
Botulinum toxin binds to the presynaptic membrane of the cholinergic nerve, inhibiting the release of acetylcholine, resulting in a loss of local cholinergic innervation. To date, there is little or no evidence that botulinum toxin inhibits acetylcholine release from parasympathetic cholinergic presynaptic terminals. In this study, the authors examined the anticholinergic effects of purified botulinum toxin A and D in the submandibular gland at non-lethal doses. The target nerve fibers are postganglionic parasympathetic neurons that run in the lingual nerve, which dominate the submandibular glands and ducts. Materials and Methods Male hybrid dogs (18 ~ 20kg) 20. Submandibular gland injection of botulinum toxin after general anesthesia. Separation of the tongue nerve in the neck, with double