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目的比较福辛普利和依那普利治疗老年人原发性高血压的疗效和安全性。方法经２周安慰剂导入期，６２例患者服用福辛普利１０ｍｇ１／ｄ或依那普利５ｍｇ１／ｄ，２周后无效则剂量加倍，４周后如仍无效则加服双氢克尿噻２５ｍｇ１／ｄ。结果两组药物均能明显降压（Ｐ＜０．００１），福辛普利降压谷峰值比率７３．９％，依那普利为４１．３％，不良反应发生率相似，依那普利有２例因不良反应退出试验。结论对老年患者福辛普利是一种有效、安全且易耐受的降压药，每日一次能维持２４小时降压效应。
Objective To compare the efficacy and safety of fosinopril and enalapril in the treatment of essential hypertension in the elderly. Methods After 2 weeks of placebo, 62 patients took fosinopril 10mg1 / d or enalapril 5mg1 / d, after 2 weeks, the dose was doubled. After 4 weeks, if the dose was still not effective, hydrochlorothiazide 25mg1 / D. Results The two groups of drugs could be significantly depressurized (P <0.001). The peak-to-peak ratio of fosinopril was 73.9% and enalapril was 41.3%. The incidence of adverse reactions was similar. Lee 2 patients withdraw from the test due to adverse reactions. Conclusion Fosinopril in elderly patients is an effective, safe and tolerable antihypertensive drugs, once a day to maintain a 24-hour antihypertensive effect.