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本文对妊娠期使用解热镇痛药——水杨酸盐类、对苯胺衍生物和呲唑酮类药物的致畸性,适应症及配伍禁忌做了讨论。阿司匹林该药的致畸性报道不一。ID Richards等人认为妊娠期单独服用阿司匹林或与其它药联用,致畸率高于未服用阿司匹林的孕妇3倍,而在美国和澳大利亚的对照研究,认为根据临床和统计学资料,尚不能确定阿司匹林的致畸性。孕妇大剂量持续服用阿司匹林能明显减轻新生儿的体重;标准剂量既不影响新生儿体重,亦不影响母亲健康。 Lewis报道103名孕妇在妊娠后期服用阿司匹林(>3g/日),明显延长了孕期,过期分娩增多,产程延长,分娩时失血明显多于未用过该药的产妇。
This article discusses the use of antipyretic analgesics during pregnancy - salicylates, p-anilines and pyrazolones teratogenicity, indications and incompatibility were discussed. Aspirin Teratogenicity of the drug reported differently. ID Richards, who believe that taking aspirin alone during pregnancy or in combination with other drugs, teratogenic rate than those who did not take aspirin 3 times, while the control study in the United States and Australia, based on clinical and statistical data, not yet determined Teratogenicity of aspirin. High doses of pregnant women taking aspirin can significantly reduce the weight of newborns; standard dose does not affect the weight of newborns, does not affect the mother’s health. Lewis reported that 103 pregnant women taking aspirin (> 3g / day) during the second trimester of pregnancy significantly prolonged their pregnancy and prolonged labor, prolonged labor, and significantly more blood loss during childbirth than those who had not used the drug.