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目的探讨早期肠内营养加谷氨酰胺(Glutamine)及微量营养补充对艾滋病患者免疫细胞及生化指标的影响。方法选取我院2014年4月-2016年7月收治的63例艾滋病患者,随机分组,对照组31例,观察组32例。对照组给予常规肠内营养补充,观察组于常规肠内营养补充基础上给予谷氨酰胺及微量营养补充强化肠内营养。观察比较两组CD_3~+、CD_4~+、CD_8~+免疫细胞水平及血清转铁蛋白(TF)、白蛋白(ALB)、前白蛋白(PA)、血红蛋白(HGB)血清生化指标水平,并统计不良反应发生情况。结果干预后观察组CD_3~+、CD_4~+、CD_8~+水平均高于对照组,差异具有统计学意义(P<0.05);干预后观察组PA、ALB、HGB、TF及NB水平均高于对照组,差异具有统计学意义(P<0.05);观察组不良反应发生率为9.38%,低于对照组的32.26%,差异具有统计学意义(P<0.05)。结论在肠内营养补充基础上加用谷氨酰胺、微量营养补充,可有效提高患者血清生化指标及免疫细胞水平,且安全性高,值得推广。
Objective To investigate the effects of early enteral nutrition plus glutamine and micronutrients on immune cells and biochemical parameters in AIDS patients. Methods Sixty-three AIDS patients admitted from April 2014 to July 2016 in our hospital were randomly divided into control group (n = 31) and observation group (n = 32). The control group was given routine enteral nutrition supplementation, and the observation group was given glutamine and micronutrient supplementation to strengthen enteral nutrition on the basis of routine enteral nutrition supplementation. The level of CD_3 ~ +, CD_4 ~ +, CD_8 ~ + immune cells and the serum biochemical indexes of serum albumin, albumin, albumin and hemoglobin in two groups were observed and compared Statistics of adverse reactions occurred. Results After intervention, the levels of CD_3 ~ +, CD_4 ~ + and CD_8 ~ + in the observation group were significantly higher than those in the control group (P <0.05). After intervention, the levels of PA, ALB, The difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 9.38%, which was lower than that in the control group (32.26%), the difference was statistically significant (P <0.05). Conclusions The addition of glutamine and micronutrient supplementation on the basis of enteral nutrition supplementation can effectively improve the serum biochemical indexes and immune cell levels in patients with high safety and is worth popularizing.