结核抗体检测的临床意义

• 作 者: 李宗琴 周彩存 田万林
• 机 构: 蚌埠医学院附属医院急诊内科
• 出 处: 蚌埠医学院学报
• 发表日期: 1998年05期
• 关键词: 结核抗体检测 肺外结核 非活动性结核 酶联免疫吸附 体腔液 活动性肺结核 免疫测定 差异有显著性 核性 结核菌感染

目的：评估结核抗体（ＴＢＡｂ）对结核病的诊断价值。方法：采用酶联免疫吸附（ＥＬＩＳＡ）试验法测定２３１例结核患者、１７０例非结核病及健康人的血清ＴＢＡｂ或体腔液的ＴＢＡｂ。结果：结核组中血清ＴＢＡｂ阳性率为７６．６％，非结核病及健康人组中的阳性率为９．４％，两组差异有显著性（Ｐ＜０．０１）。结核性体腔液ＴＢＡｂ阳性率为８５．９％，非结核性体腔液阳性率为５．０％，差异有显著性（Ｐ＜０．００５）。结论：ＥＬＩＳＡ法检测ＴＢＡｂ是诊断肺结核及肺外结核的一项有效的辅助诊断手段。同时进行血清及体腔液的ＴＢＡｂ测定，可提高结核的诊断率。

Objective: To evaluate the diagnostic value of tuberculosis antibody (TBAb) to tuberculosis. Methods: The enzyme-linked immunosorbent assay (ELISA) was used to determine the TBAb in 231 TB patients and 170 non-TB patients and healthy volunteers. Results: The positive rate of TBAb in tuberculosis group was 76.6%, and that in non-tuberculosis and healthy people was 9.4%. There was significant difference between the two groups (P <0.01). Tuberculous body fluid TB  Ab positive rate was 85.9%, non-tuberculous body fluid positive rate was 5.0%, the difference was significant (P <0.005). Conclusion: ELISA TB-Ab is an effective diagnostic tool for the diagnosis of tuberculosis and extrapulmonary tuberculosis. At the same time serum and body fluid TB  Ab determination, can improve the diagnostic rate of tuberculosis.