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目的研究原发性肝细胞癌中Ｐ１６蛋白的表达程度与转移及预后的关系．方法应用免疫组织化学ＬＳＡＢ法对４５例原发性肝细胞癌组织及癌旁组织进行Ｐ１６蛋白表达的检测，并结合临床资料进行分析．结果肝癌肿瘤区及癌旁区Ｐ１６蛋白阳性表达率分别为４００％和８４４％，两组比较，有显著性差异（Ｐ＜００５）．Ｐ１６蛋白阳性表达率在无转移的肝癌中为６０５％，有转移组为２００％；高、中和低分化的肝癌分别为５００％，２７８％和２２２％．故Ｐ１６蛋白阳性表达在肝癌患者高分化与中和低分化比较有显著性差异（Ｐ＜００５），转移与非转移组比较有极显著性差异（Ｐ＜００１）．结论Ｐ１６蛋白表达与肝细胞癌增殖、分化程度及预后有关
5. Objective To study the relationship between the expression of P16 protein and metastasis and prognosis in primary hepatocellular carcinoma. Methods Immunohistochemical LSAB method was used to detect the expression of P16 protein in 45 cases of primary hepatocellular carcinoma and paracancerous tissues. The results were analyzed with clinical data. Results The positive rate of P16 protein expression in tumor area and paracancerous area of hepatocellular carcinoma was 40.0% and 84.4%, respectively. There was a significant difference between the two groups (P<005). The positive expression rate of P16 protein was 60.5% in non-metastatic liver cancer, and 20.0% in metastatic group, and 50.0%, 27.8%, and 22.2% in high, medium, and poorly differentiated liver cancer, respectively. . Therefore, the positive expression of P16 protein in liver cancer patients with high differentiation and moderate and poor differentiation compared with significant difference (P <0 05), metastasis and non-metastasis group was very significant difference (P <0 01). Conclusion The expression of P16 protein is related to the proliferation, differentiation and prognosis of hepatocellular carcinoma