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为克服新西兰白兔（NZW）作为实验动物稳定性差的技术问题，复制符合临床特征的稳定的MODS动物模型。以“肠源性感染”及“失血性休克”作为两次打击，诱发MODS，比较在不同的实验条件下，MODS发生率的差异，摸索最佳实验条件。在最佳实验条件下，脏器功能障碍发生率91．7％，MODS发生率75％，组间比较P＜0．01。结果提示：在一定感染细菌量的条件下，血压的严格控制对成功复制MODS模型最为关键，其他的重要因素为一定的支持手段，适当的手术创伤等。
In order to overcome NZW as a technical problem of poor stability in experimental animals, a stable MODS animal model consistent with clinical features was replicated. MODS was induced by “gut-derived infection” and “hemorrhagic shock”, and the differences of MODS incidence under different experimental conditions were compared to explore the optimal experimental conditions. Under the optimal experimental conditions, the incidence of organ dysfunction was 91.7%, the incidence of MODS was 75%, P <0.01. The results suggest that strict control of blood pressure is the most crucial factor in the successful replication of MODS under the condition of certain amount of bacterial infection. Other important factors are certain supportive measures, appropriate surgical trauma, and the like.