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本文综述肿瘤坏死因子(TNF)的基因结构特点,某些化学药物,微生物和IFN-γ、GM-CSF、IL-2、4、6等细胞因子和TNF本身在转录水平、转录后水平和翻译水平上对TNF基因表达的调节作用,这些因素相互间的抑制、协同或促进作用以及由此形成的复杂的分泌调节环路。现知TNF不仅由Mo/Mφ产生,多种不同谱系的细胞,如中性粒细胞、嗜碱性粒细胞、肥大细胞、淋巴细胞等均可产生.除肿瘤细胞外,TN(?)还对多种靶细胞具有广泛的生物学功能。TNF还与某些病理状态相关.
This review summarizes the structural features of tumor necrosis factor (TNF) genes, the transcriptional level, post-transcriptional level, and translation of certain chemotherapeutic agents, microbes and cytokines such as IFN-γ, GM-CSF, IL-2, The regulatory role of TNF gene expression horizontally, the mutual inhibition of these factors, the synergistic or facilitation effect, and the resulting complex secretion regulatory loop. It is known that TNF is not only produced by Mo / Mφ, but also produced by cells of many different lineages, such as neutrophils, basophils, mast cells, lymphocytes, etc. In addition to tumor cells, TN A variety of target cells have a wide range of biological functions. TNF is also associated with certain pathological conditions.