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目的:分析热毒宁注射液所致不良反应发生的规律和特点,为临床合理用药提供依据。方法:选取2009年—2014年间收集的34例热毒宁注射液所致ADR患者,分析患者性别、年龄以及给药途径、溶媒、原发疾病、联合用药、不良反应发生的部位和转归等情况。结果:34例热毒宁注射液所致ADR患者均为10岁以内儿童,1~8岁者占88.24%;联合用药后发生ADR者为24例(70.59%);原发疾病以呼吸道感染为主,临床表现主要为药物性皮疹、过敏反应等皮肤及附件表现,发生不良反应在30 min内为26例(76.47%),停药后2 h内均可恢复;无严重ADR发生。结论:临床使用热毒宁注射液应遵循中医辨证论治的指导原则,按照其说明书的要求,选择合适的溶媒,尽量避免联合用药,联用药物应用皮条冲洗,同时密切观察用药的全过程,尤其是观察用药30 min内药物不良反应的发生,提高临床用药安全意识,尽可能减少或避免不良反应的发生。
OBJECTIVE: To analyze the regularities and characteristics of adverse reactions caused by Rendunning injection and provide the basis for rational clinical use. Methods: ADR patients were selected from 34 cases treated with Renduining injection between 2009 and 2014. The gender, age, route of administration, vehicle, primary disease, combination therapy, location and prognosis of adverse reactions were analyzed Happening. Results: 34 cases of ADR patients caused by Revedun injection were children under 10 years old, 88.24% of whom were aged 1 to 8 years old. 24 cases (70.59%) had ADR after combination therapy. The primary disease was respiratory infection The main clinical manifestations of skin rash, allergic reactions such as skin and appendages, the occurrence of adverse reactions in 26 patients (76.47%) within 30 min, withdrawal within 2 h after recovery; no serious ADR. Conclusion: The clinical use of Rendunning injection should follow the guiding principle of syndrome differentiation and treatment of traditional Chinese medicine, in accordance with the requirements of its instructions, select the appropriate solvent, try to avoid combination therapy, combined with the application of leather washing, and close observation of the whole process of medication, especially Observe the occurrence of adverse drug reactions within 30 min, improve the consciousness of clinical medication safety and minimize or avoid the occurrence of adverse reactions.