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目的探讨胃癌患者血清中LAG-3、DKK-1水平与胃癌病理类型及临床预后的关系。方法选取经病理确诊的胃癌患者60例,采用酶联免疫吸附法(ELISA法)检测胃癌患者血清中LAG-3、DKK-1的含量,探讨各蛋白表达水平与胃癌病理类型及临床预后的关系。结果伴有淋巴结转移的胃癌患者血清DKK-1、LAG-3水平高于无淋巴结转移的患者,差异有统计学意义(P<0.05);TNM分期为Ⅳ期的患者DKK-1、LAG-3水平高于其他分期患者,差异有统计学意义(P<0.05);低分化的胃癌DKK-1、LAG-3水平高于高分化和中分化组,差异有统计学意义(P<0.05);TNM分期、DKK-1、LAG-3水平是胃癌患者死亡的独立风险因素(P<0.05)。结论胃癌患者血清中LAG-3、DKK-1水平与胃癌病理类型及临床预后密切相关。
Objective To investigate the relationship between the serum levels of LAG-3 and DKK-1 in patients with gastric cancer and the pathological types and clinical prognosis of gastric cancer. Methods Sixty patients with pathologically diagnosed gastric cancer were selected. The levels of LAG-3 and DKK-1 were detected by enzyme-linked immunosorbent assay (ELISA), and the relationship between the expression of LAG-3, DKK-1 and the pathological type and clinical prognosis of gastric cancer . Results The serum levels of DKK-1 and LAG-3 in patients with lymph node metastasis were significantly higher than those without lymph node metastasis (P <0.05). The levels of DKK-1 and LAG-3 in TNM stage Ⅳ patients (P <0.05). The levels of DKK-1 and LAG-3 in poorly differentiated gastric cancer were significantly higher than those in well-differentiated and moderately differentiated groups (P <0.05). The difference was statistically significant (P < TNM staging, DKK-1, and LAG-3 levels were independent risk factors for gastric cancer death (P <0.05). Conclusion Serum levels of LAG-3 and DKK-1 in gastric cancer patients are closely related to the pathological type and clinical prognosis of gastric cancer.