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目的:观察氧化应激损伤反应在冠心病心肌缺血血瘀证中的变化规律。方法:ELISA测定氧化应激关键分子超氧化物歧化酶(SOD)、丙二醛(MDA)、细胞色素C(Cyto C)、一氧化氮(NO)、肿瘤坏死因子(TNF-α)等浓度。结果:氧化应激损伤反应贯穿了血瘀证的始终,与血瘀证密切相关的炎症因子TNF-α与反应内皮功能损伤程度的NO变化趋势与氧化应激损伤程度一致。结论:氧化应激反应参与了血瘀证早期的形成,并诱导了炎症反应与内皮功能的障碍,而Cyto C能比较敏感地反应氧化应激损伤的程度。
Objective: To observe the changes of oxidative stress injury in myocardial ischemia and blood stasis syndrome of coronary heart disease. Methods: The concentrations of superoxide dismutase (SOD), malondialdehyde (MDA), cytochrome C (NO), tumor necrosis factor (TNF-α) . Results: Oxidative stress injury reaction throughout the blood stasis syndrome, and blood stasis syndrome closely related to the inflammatory cytokines TNF-α and reactive endothelial dysfunction, NO trend and oxidative stress injury consistent. CONCLUSION: Oxidative stress is involved in the early formation of blood stasis syndrome and induces the barrier of inflammatory reaction and endothelial function. Cyto C can reflect the degree of oxidative stress more sensitively.