论文部分内容阅读
左旋咪唑(Levamisole简称LMS),原是一种人工合成的广谱低毒驱虫药。近年来作为免疫调节剂,在治疗某些免疫功能缺陷或某些难治性疾病方面,已颇受重视,且应用范围日益广泛。经临床使用证明,LMS的副作用较多,其发生率可高达15～20％。故应引起注意。 一、过敏反应 黄氏等报道该院3例女性成年病人服用LMS治疗钩虫病,均顿服150mg,7～8小时后出现寒战高热,体温高达40℃以上,头晕呕吐,呼吸衰竭,其中一例死亡。另有报道服药后全身不适,热性肌痛、胸痛、关节痛、出汗、咽喉痛等流感样综合征表现及全身猩红热样皮疹。Secher认为该药既可引起Ⅰ型过敏,也可以引起Arthus型过敏。大多数的头晕、恶心不适表现轻微,反应持续时间短,不经处理,自行消失。
Levamisole (Levamisole referred to as LMS), was originally a synthetic broad-spectrum low toxicity deworming drug. In recent years, as immunomodulators, in the treatment of certain immune dysfunction or some refractory diseases, has received considerable attention, and the application of a growing range. Proved by clinical use, LMS more side effects, the incidence can be as high as 15 to 20%. It should attract attention. First, the allergic reaction Huang et al reported that the hospital 3 cases of female adult patients taking LMS treatment hookworm disease, average Dayton clothing 150mg, 7 to 8 hours after the chills fever, body temperature up to 40 ℃, dizziness and vomiting, respiratory failure, one case death. Another reported systemic malaise, heat myalgia, chest pain, joint pain, sweating, sore throat and other flu-like syndrome and systemic scarlet fever-like rash. Secher believes that the drug can cause type I allergy, can also cause Arthus allergy. Most dizziness, nausea and discomfort showed mild, short duration of response, left untouched.