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目的:探讨减少优质胚胎移植数目对重复体外受精-胚胎移植(IVF-ET)患者妊娠结局的影响。方法:回顾性分析重复IVF-ET治疗的不孕患者427个周期,根据胚胎移植数分为2枚组和3枚组,分别比较年龄<35岁患者及年龄≥35岁患者移植2枚或3枚优质胚胎的妊娠结局。结果:年龄<35岁患者中,重复周期移植2枚优质胚胎组与3枚组临床妊娠率、流产率和活产率均无明显差异(P>0.05),但2枚组多胎妊娠率显著低于3枚组(P<0.05),新生儿体重显著高于3枚组(P<0.05);年龄≥35岁患者中,两组妊娠率、流产率、活产率和新生儿体重均无差异,但2枚组多胎妊娠率显著低于3枚组(P<0.05)。结论:对于不同年龄段重复周期患者,移植优质胚胎数从3枚减少到2枚,并不会明显降低临床妊娠率,但可减少多胎妊娠的发生,获得更好的妊娠结局。
Objective: To investigate the effect of reducing the number of high-quality embryos on pregnancy outcomes in patients with repeated IVF-ET (IVF-ET). Methods: 427 cycles of IVF-ET-treated infertile patients were retrospectively analyzed. According to the number of embryo transfer, the patients were divided into two groups and three groups. The patients with age less than 35 years and the patients with age more than 35 years were compared with 2 or 3 Pregnancy outcome of a high quality embryo. Results: There was no significant difference in clinical pregnancy rate, abortion rate and live birth rate between two high quality embryo group and three pregnancy group (P> 0.05), but the pregnancy rate of two groups was significantly lower There were no significant differences in pregnancy rate, miscarriage rate, live birth rate and newborn weight between the three groups (P <0.05), the newborn weight was significantly higher than the three groups (P <0.05) , But the incidence of multiple pregnancy in the two groups was significantly lower than that in the three groups (P <0.05). CONCLUSIONS: The number of high quality embryos transferred from 3 to 2 for patients of different ages and repetitive cycles does not significantly reduce clinical pregnancy rates, but can reduce the incidence of multiple pregnancies and achieve better pregnancy outcomes.