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慢性淋巴细胞白血病(慢淋)是以B淋巴细胞单克隆增生为特征的疾病,而T细胞又能对B细胞的调节起关键性作用,因此临床要认识本病无疑须全面正确地评价这两类淋巴细胞所发生的各种现象。作者在4年内对60例慢淋患者的淋巴细胞的各种表面标志与临床表现、病程间的关系进行了研究。慢淋诊断时的疾病分期按Rai标准。15例Ⅲ～Ⅳ期患者从诊断起的中位生存期是3年,45例早期患者则是7年,说明Rai分期对测定病人组的预后一般是有用的。本组合并第二个原发性恶性肿瘤的发生率是20％,且大多数发生于慢淋诊断之前。18例作了Coombs试验6例阳性,其中3例并发溶血性贫血。
Chronic lymphocytic leukemia (CLL) is a disease characterized by mononuclear proliferation of B lymphocytes, which in turn plays a key role in the regulation of B cells. Therefore, it is undoubtedly necessary to fully evaluate these two A variety of phenomena that occur in lymphoid cells. The authors studied the relationship between various surface markers of lymphocytes and clinical manifestations and duration of disease in 60 patients with chronic lymphocytic leukemia within 4 years. Rin disease diagnosis of disease staging according to Rai standard. The median survival of 15 patients with stage III-IV disease was 3 years from diagnosis and 45 years were 7 years, indicating that Rai stage is generally useful in determining the prognosis of a patient group. The group combined with the incidence of the second primary malignancy was 20%, and most occurred before the diagnosis of chronic lymph node. 18 cases were Coombs test 6 cases were positive, of which 3 cases complicated by hemolytic anemia.