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尽管儿科实践中类固醇应用广泛,但合并胃肠道问题是罕见的。作者报告2例患儿在免疫抑制剂治疗白血病时发生了十二指肠溃疡穿孔。例1,6岁男孩因剧烈上腹痛从睡眠中醒来6小时入院。3月前发现其患混合的粒细胞性和淋巴细胞性白血病,门诊给予化疗。开始12天用强的松龙20mg 2日,总量已达500mg。不发热,脉搏正常,但有上腹部痛,呈板状。X 线检查证实左膈下有游离气体而确诊穿孔。平素无消化道症状及溃疡病家族史。给以补液、类固醇和抗生素后剖腹探查见穿孔位于十二指肠第一段前壁,缝后用
Despite the widespread use of steroids in pediatric practice, the combination of gastrointestinal problems is rare. The authors report 2 children with duodenal ulcer perforation at immunosuppressant treatment of leukemia. Example 1,6-year-old boy wakes up from sleep for 6 hours due to severe upper abdominal pain. 3 months ago found that it had mixed granulocytic and lymphocytic leukemia, outpatient chemotherapy. The first 12 days with prednisolone 20mg 2, the total has reached 500mg. No fever, normal pulse, but upper abdominal pain, was plate-like. X-ray examination confirmed that there is free gas left under the diaphragm perforated. Usually no gastrointestinal symptoms and family history of ulcer disease. To give fluid, steroids and antibiotics after laparotomy see perforation is located in the first paragraph of the anterior duodenum, after the seam with