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高效联合抗反转录病毒治疗已明显改善HIV感染者的预后,HIV耐药是影响抗反转录病毒治疗疗效的重要因素。在未接受抗反转录病毒治疗的HIV感染中亦可检测到HIV耐药突变(即HIV传播耐药)。HIV传播耐药可导致后续抗反转录病毒治疗疗效的下降或失败,其在人群的进一步传播及流行成为重要的公共卫生问题。作者就HIV传播耐药的现有检测方法、国内外流行现状以及耐药检测的临床意义作一综述。
Efficient combination of antiretroviral therapy has significantly improved the prognosis of HIV-infected persons, and HIV resistance is an important factor affecting the efficacy of antiretroviral therapy. HIV-resistant mutations (ie, HIV transmission-resistant) can also be detected in HIV-infected patients who have not received antiretroviral therapy. Resistance to HIV transmission can lead to the decline or failure of follow-up antiretroviral therapy, and its further spread and spread in the population have become important public health issues. The authors reviewed the current detection methods of HIV transmission, the prevalence at home and abroad, and the clinical significance of drug resistance testing.