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目的探讨肿瘤抑制基因P53和增殖细胞核抗原（PCNA）与子宫内胰腺癌生物学行为的关系。方法采用免疫组织化学（ABC）法，检测28例子宫内膜腺癌和36使子宫内膜增殖症组织中的P”和PCNA的表达状况。结果①肿瘤抑制基因P53蛋白在子宫内膜腺癌中的阳性表达率为50％（14／28）。每高倍视野（40×）内P53免疫阳性细胞数为224±35。而在子宫内股增殖症中未见P53蛋白表达，差异非常显著（P＜0．01）。②PCNA在子宫内胰腺癌和子宫内膜增殖症中均有表达，但每高倍视野内PCNA免疫阳性细胞数前者（274±70）明显高于后者（121±44），有显著性差异。③子宫内膜腺癌组织中P53免疫阳性细胞数与PCNA呈明显正相关（r=0．798，P＜0．01）结论肿瘤抑制基因P53蛋白表达可能与细胞增殖状况及于子宫内膜腺癌的恶性生物学行为有关。
Objective To investigate the relationship between tumor suppressor gene P53 and proliferating cell nuclear antigen (PCNA) and the biological behavior of uterine pancreatic cancer. Methods The expression of P "and PCNA in 28 cases of endometrial adenocarcinoma and 36 cases of endometrial hyperplasia were detected by immunohistochemistry (ABC) method.Results ① The expression of P53 protein in endometrial adenocarcinoma (P <0.05), while the positive expression rate of P53 in each high power field (40 ×) was 224 ± 35.While there was no P53 protein expression in intrauterine femoral hyperplasia, the difference was significant (P <0.01) .②PCNA was expressed in both uterine pancreatic cancer and endometrial hyperplasia, but the number of PCNA positive cells in each high power field (274 ± 70) was significantly higher than that in the latter (121 ± 44) (P <0.01) .Conclusion The expression of P53 protein in endometrial adenocarcinoma may play an important role in the proliferation of PCNA, It is related to the malignant biological behavior of endometrial adenocarcinoma.