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目的:探讨18F氟脱氧葡萄糖(18F-fluorodeoxyglucose,18F-FDG)正电子发射断层显像术(positron-emission tomography,PET)/计算机体层摄影术(computed tomography,CT)在宫颈癌初诊及随访监测中的价值。方法:回顾性分析72例宫颈病变患者的18F-FDGPET/CT检查结果及其他临床相关资料。43例初诊疑似宫颈癌的初诊患者行18F-FDGPET/CT检查用于诊断分期和术前评估,29例既往接受过手术、化疗和(或)放疗的宫颈癌患者行18F-FDGPET/CT检查用于随访监测有无肿瘤复发或转移。结果:初诊组43例患者中,18F-FDGPET/CT诊断宫颈癌的敏感度、特异度和准确度分别为83.8%、50.0%和79.1%;31例宫颈癌患者中,淋巴结转移率为38.7%(12/31)。随访监测组29例患者中,11例患者有肿瘤复发、残余和转移,18F-FDGPET/CT诊断的敏感度、特异度和准确度分别为100%、77.8%和86.2%;45.5%(5/11)被检出有小淋巴结转移灶,63.6%(7/11)被检出有远处转移。结论:18F-FDGPET/CT用于宫颈癌初诊及随访监测具有较高的敏感度和特异度,有助于进行准确的临床分期,并及时发现肿瘤的复发、残余和远处转移。
OBJECTIVE: To investigate the clinical value of 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET) / computed tomography (CT) In the value. Methods: The clinical data of 18F-FDG PET / CT in 72 cases of cervical lesions were analyzed retrospectively. Forty-three newly diagnosed cervical cancer-newly diagnosed patients underwent 18F-FDG PET / CT examinations for the diagnosis of staging and preoperative evaluation. Twenty-nine patients with cervical cancer who had previously undergone surgery, chemotherapy and / or radiotherapy were treated with 18F-FDG PET / CT Follow-up monitoring of tumor recurrence or metastasis. Results: The sensitivity, specificity and accuracy of 18F-FDG PET / CT in diagnosis of cervical cancer were 83.8%, 50.0% and 79.1% respectively in 43 cases of newly diagnosed group; in 31 cases of cervical cancer, the rate of lymph node metastasis was 38.7% (12/31). The follow-up monitoring group of 29 patients, 11 patients with tumor recurrence, residual and metastasis, 18F-FDG PET / CT diagnosis of sensitivity, specificity and accuracy were 100%, 77.8% and 86.2%; 45.5% 11) were detected with small lymph node metastases, 63.6% (7/11) were detected distant metastasis. Conclusion: 18F-FDG PET / CT has high sensitivity and specificity for newly diagnosed cervical cancer and follow-up monitoring, which is helpful for accurate clinical staging and timely detection of tumor recurrence, remnant and distant metastasis.