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大量研究表明,依赖Ca2+、Zn2+等金属离子的基质金属蛋白酶在动脉粥样硬化斑块处的表达与斑块的稳定性密切相关,易损斑块处基质金属蛋白酶表达水平增高。单光子发射体层成像、近红外荧光成像、磁共振成像等分子影像学的方法,能够动态无创地检测动物模型动脉斑块或人颈动脉斑块切除后标本中基质金属蛋白酶的表达水平,不仅可以提示疾病的发展进程,而且能够评价药物的治疗效果。尽管大多数斑块成像的分子影像学手段尚未达到临床应用的阶段,但合成多模态的分子探针,综合运用各种不同的影像学方法将是动脉粥样硬化斑块成像的发展方向。
Numerous studies have shown that the expression of matrix metalloproteinase (MMP) dependent on Ca2 +, Zn2 + and other metal ions in atherosclerotic plaque is closely related to the stability of plaque, and the expression level of MMPs in vulnerable plaque increases. Single photon emission tomography, near-infrared fluorescence imaging, magnetic resonance imaging and other molecular imaging methods can dynamically and noninvasively detect the expression level of matrix metalloproteinase in the animal model plaque or human carotid plaque resection specimen Can prompt the development of the disease, but also to evaluate the therapeutic effect of the drug. Although most molecular imaging modalities for plaque imaging have not yet reached the clinical stage of application, the synthesis of multimodal molecular probes, combined with different imaging methods, will be the development of atherosclerotic plaque imaging.