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肝纤维化(HF)是各种致病原因引起细胞外基质(ECM)在肝内过多沉积的过程,它是大多数慢性肝病所共有的病理特征,是众多慢性肝病发生发展的必经阶段。研究业已证明,肝星状细胞(HSC)在肝纤维化的发生发展过程中发挥关键作用。在损伤因子作用下,HSC增殖、活化,产生细胞外基质(ECM),是肝纤维化发生的关键细胞、重要环节[1]。进展性肝纤维化具有一定的可逆性,现就其治疗研究进展综述如下。
Hepatic fibrosis (HF) is the process by which extracellular matrix (ECM) is excessively deposited in the liver due to a variety of pathogenic causes. It is a common pathological feature of most chronic liver diseases and is a necessary stage for the development of many chronic liver diseases . Studies have shown that hepatic stellate cells (HSCs) play a key role in the development of hepatic fibrosis. Under the action of damaging factor, HSC proliferates and activates and produces extracellular matrix (ECM), which is the key cell and important link of hepatic fibrosis [1]. Progressive liver fibrosis has a certain degree of reversibility, the progress of its treatment are summarized below.