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【目的】 了解广州市新生儿围产期HBV的感染情况。 【方法】 采用酶联免疫吸附试验 (ELISA)和斑点杂交技术对 2 41例新生儿脐血的乙肝病毒标志物进行检测。 【结果】 广州市新生儿围生期HBsAg阳性率为2 .0 7% (5 /2 41) ,HBsAg阴性、单纯Anti HBc阳性且HBVDNA阳性者 19例 ,占 7.89% (19/2 41) ,新生儿脐血HBV感染率为 9.96 % (2 4/2 41) ,现症HBV感染母亲的新生儿脐血HBV感染率为 72 .73 % (2 4/33) ;母亲与新生儿Anti HBs抗体浓度的相关系数为r =0 .85 ,P =0 .0 0 0 1;新生儿与母亲Anti HBs阳性关联系数为 0 .78,阳性率无差异。 【结论】 现症HBV感染母亲新生儿围产期HBV感染率高 ,以单纯Anti HBs阳性且HBVDNA阳性为主要表现形式 ;母亲Anti HBs阳性者新生儿脐血基本阳性 ,母亲与婴儿Anti HBs浓度明显相关
【Objective】 To understand the neonatal perinatal HBV infection in Guangzhou. 【Method】 Two hundred and seventy-four newborns with cord blood hepatitis B virus markers were detected by enzyme-linked immunosorbent assay (ELISA) and dot blot hybridization. 【Results】 The positive rate of HBsAg in perinatal neonates was 2. 0 7% (5/141) in Guangzhou, HBsAg negative, anti-HBc positive and HBVDNA positive in 19 cases (7.89%, 19/2 41) The neonatal cord blood HBV infection rate was 9.96% (24/241), the incidence of HBV infection in neonates with HBV-infected mothers was 72.73% (2/4/33). Anti-HBs antibodies in mothers and newborns The correlation coefficient of concentration was r = 0 .85, P = 0.00001. The positive correlation coefficient of anti HBs between newborns and mothers was 0.78, and the positive rate was no difference. 【Conclusion】 The incidence of perinatal HBV infection in mothers with HBV infection is high, with Anti HBs positive and HBVDNA positive as the main manifestation. The mothers with anti HBs-positive neonatal cord blood are basically positive, and the concentrations of Anti HBs in mothers and babies are obvious Related