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目的 研究血中红细胞压积 (hematocrit,Hct)、血红蛋白浓度 (haemoglobin ,Hb)及白蛋白浓度 (albu min ,Alb)等因素与他克莫司 (tacrolimus,FK5 0 6 )相对清除率 (relativeclearance ,RC)之间的相关性 ,并初步探讨其临床应用价值。方法 对 5 9例接受同种异体尸肾移植的受者采用了以FK5 0 6为基础的三联药物免疫抑制治疗 ,监测其FK5 0 6全血浓度谷值 (troughconcentration ,Cmin) ,并同时监测血中Hct,Hb ,Alb ,FK5 0 6剂量及患者体重的变化 ,将Hct,Hb及Alb与FK5 0 6相对清除率进行相关性检验。结果 FK5 0 6相对清除率 (RC)与Hct,Hb ,Alb之间相关性检验有统计学意义 ,P值分别为 0 0 2 8,0 0 31,0 0 0 1,相关系数r值分别为 - 0 76 1,- 0 75 2 ,- 0 917;Hct与Hb之间相关性检验有统计学意义 ,P <0 0 0 1,相关系数r值为 0 96 8。结论 监测血中Hct,Hb ,Alb的水平值及其动态变化情况 ,可以初步估测FK5 0 6的RC和Cmin的水平值及其动态变化情况 ,在FK5 0 6首剂给药剂量的个体化及血药浓度监测频率调整等方面有一定的临床价值
Objective To study the relative clearance of hematocrit (Hct), hemoglobin (Hb), albumin (Alb) and tacrolimus (FK5 0 6) RC) between the correlation and preliminary study of its clinical value. Methods Fifty-nine recipients of allogeneic cadaveric kidney transplantation were treated with triple immunosuppressive drugs based on FK506 to monitor the trough concentration (Cmin) of the FK506 whole blood and to monitor blood Hb, Alb, FK506 in patients with body weight changes, the relative clearance of Hct, Hb and Alb and FK5 06 correlation test. Results The correlation between relative clearance (RC) and Hct, Hb and Alb in FK5 0 6 was statistically significant (P = 0 0 2 8, 0 0 31, 0 0 0 1, respectively) and the correlation coefficient r was - 0 76 1, - 0 75 2, - 0 917; The correlation test between Hct and Hb was statistically significant, P <0 0 0 1, the correlation coefficient r was 0 96 8. Conclusion The levels of Hct, Hb and Alb in blood and their dynamic changes can be estimated by preliminary evaluation of the level and dynamic changes of RC and Cmin in FK506. When the dose of FK506 is administered individually And blood plasma concentration monitoring frequency adjustment has certain clinical value