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对生前经过痴呆调查与临床诊断的９例老人院住院老人死亡后进行尸解与神经病理学观察。结果发现９例尸检脑均有不同程度的萎缩与锥体细胞减少，脂褐素沉积，胶质细胞增生，淀粉样小体存在。其中３例尚在皮层与海马中发现大量老年斑（ＳＰｓ）与神经原纤维缠结（ＮＦＴｓ），病理确诊为Ａｌｚｈｅｉｍｅｒ病（ＡＤ）；其余６例明确为非Ａｌｚｈｅｉｍｅｒ病老年脑（ＮＡＤ）。该病理结果与临床诊断全部符合，提示ＮＩＮＣＤＳ－ＡＤＲＤＡ之ＡＤ临床诊断标准的可靠性及实用性。作者强调反复临床检查与随访能显著提高ＡＤ临床诊断的准确性与可靠性。
The autopsy and neuropathological observation of 9 elderly inpatients who died of dementia investigation and clinical diagnosis before their death were performed. The results showed that 9 cases of autopsy of the brain have varying degrees of atrophy and pyramidal cell reduction, lipofuscin deposition, glial cell proliferation, the presence of amyloid. Three of them were still found in the cortex and hippocampus a large number of age-related plaques (SPs) and neurofibrillary tangles (NFTs), the pathological diagnosis of Alzheimer’s disease (AD); the remaining 6 cases were clearly non-Alzheimer’s disease in the brain (NAD). The pathological results and clinical diagnosis all in line, suggesting that the NINCDS-ADRDA AD clinical diagnostic criteria of reliability and practicality. The authors emphasize that repeated clinical examination and follow-up can significantly improve the accuracy and reliability of clinical diagnosis of AD.